Drug interactions
Bazedoxifene / conjugated estrogens + Ciprofloxacin
Severity: Minor
Bazedoxifene / conjugated estrogens and Ciprofloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics were once thought to lower estrogen levels by disrupting gut flora, but evidence of reduced efficacy is weak. Clinically important loss of effect is unlikely.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Ciprofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction of enterohepatic estrogen recycling through altered gut flora; not well established.
What to do
No action is generally required. Report breakthrough bleeding or recurrence of menopausal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Ciprofloxacin?
MediHelp rates the interaction as minor. Bazedoxifene / conjugated estrogens and Ciprofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics were once thought to lower estrogen levels by disrupting gut flora, but evidence of reduced efficacy is weak. Clinically important loss of effect is unlikely.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Ciprofloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally required. Report breakthrough bleeding or recurrence of menopausal symptoms.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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