Drug interactions
Bazedoxifene-conjugated estrogens + Cyclosporine
Severity: Moderate
Bazedoxifene-conjugated estrogens and Cyclosporine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits CYP3A4 and P-glycoprotein and may increase exposure to bazedoxifene and estrogens. Estrogens can also raise cyclosporine levels, so the effect may run in both directions.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein reduces clearance and efflux of the hormone components.
What to do
Monitor for estrogenic adverse effects and review the ongoing need for therapy. Check cyclosporine trough levels when starting or stopping the estrogen product.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Cyclosporine?
MediHelp rates the interaction as moderate. Bazedoxifene-conjugated estrogens and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine inhibits CYP3A4 and P-glycoprotein and may increase exposure to bazedoxifene and estrogens. Estrogens can also raise cyclosporine levels, so the effect may run in both directions.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects and review the ongoing need for therapy. Check cyclosporine trough levels when starting or stopping the estrogen product.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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