Drug interactions
Bazedoxifene-conjugated estrogens + Deferasirox
Severity: Moderate
Bazedoxifene-conjugated estrogens and Deferasirox: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can lower exposure to CYP3A4-metabolized drugs, and conjugated estrogens and bazedoxifene may therefore be less effective. Reduced estrogen exposure could lead to return of menopausal symptoms, and reduced bazedoxifene exposure could lessen endometrial protection.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Deferasirox belongs to Miscellaneous.
Why it happens
Deferasirox appears to induce CYP3A4-mediated metabolism, increasing clearance of estrogen and bazedoxifene.
What to do
Monitor for recurrence of vasomotor symptoms and for abnormal uterine bleeding. Adjust therapy if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Deferasirox?
MediHelp rates the interaction as moderate. Bazedoxifene-conjugated estrogens and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can lower exposure to CYP3A4-metabolized drugs, and conjugated estrogens and bazedoxifene may therefore be less effective. Reduced estrogen exposure could lead to return of menopausal symptoms, and reduced bazedoxifene exposure could lessen endometrial protection.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Deferasirox?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for recurrence of vasomotor symptoms and for abnormal uterine bleeding. Adjust therapy if efficacy is lost.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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