Drug interactions
Bazedoxifene-conjugated estrogens + Demeclocycline
Severity: Minor
Bazedoxifene-conjugated estrogens and Demeclocycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracyclines were theorized to reduce estrogen recirculation through effects on gut flora. Good evidence of a clinically relevant reduction is lacking.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Demeclocycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction of enterohepatic recycling of estrogens due to altered intestinal flora.
What to do
No dose change is needed. Watch for return of menopausal symptoms or unexpected bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Demeclocycline?
MediHelp rates the interaction as minor. Bazedoxifene-conjugated estrogens and Demeclocycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tetracyclines were theorized to reduce estrogen recirculation through effects on gut flora. Good evidence of a clinically relevant reduction is lacking.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Demeclocycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Watch for return of menopausal symptoms or unexpected bleeding.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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