Drug interactions
Bazedoxifene / conjugated estrogens + Desipramine
Severity: Minor
Bazedoxifene / conjugated estrogens and Desipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens may alter tricyclic antidepressant exposure and effect, with reports of higher tricyclic concentrations and increased adverse effects. The clinical significance is uncertain and interactions are uncommon.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Desipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Estrogens may inhibit hepatic metabolism of tricyclics; the mechanism is not well established.
What to do
No routine change is needed. Monitor for tricyclic adverse effects such as sedation, dry mouth or tachycardia, and adjust the desipramine dose according to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Desipramine?
MediHelp rates the interaction as minor. Bazedoxifene / conjugated estrogens and Desipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens may alter tricyclic antidepressant exposure and effect, with reports of higher tricyclic concentrations and increased adverse effects. The clinical significance is uncertain and interactions are uncommon.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Desipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor for tricyclic adverse effects such as sedation, dry mouth or tachycardia, and adjust the desipramine dose according to response.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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