Drug interactions
Bazedoxifene-conjugated estrogens + Diltiazem
Severity: Moderate
Bazedoxifene-conjugated estrogens and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem inhibits CYP3A4 and may increase concentrations of conjugated estrogens and bazedoxifene. Higher exposure could raise estrogen-related adverse effects such as breast tenderness, fluid retention, or bleeding.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Diltiazem belongs to Cardiovascular.
Why it happens
Diltiazem is a moderate CYP3A4 inhibitor that reduces the metabolism of estrogens and bazedoxifene.
What to do
Monitor for estrogenic adverse effects such as breast tenderness and uterine bleeding. Use the lowest effective dose of the hormone combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Diltiazem?
MediHelp rates the interaction as moderate. Bazedoxifene-conjugated estrogens and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem inhibits CYP3A4 and may increase concentrations of conjugated estrogens and bazedoxifene. Higher exposure could raise estrogen-related adverse effects such as breast tenderness, fluid retention, or bleeding.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects such as breast tenderness and uterine bleeding. Use the lowest effective dose of the hormone combination.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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