Drug interactions
Bazedoxifene-conjugated estrogens + Lamotrigine
Severity: Moderate
Bazedoxifene-conjugated estrogens and Lamotrigine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens can lower lamotrigine concentrations, as seen with estrogen-containing contraceptives. Reduced levels may lead to loss of seizure or mood control, and the effect may reverse when the estrogen is stopped.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Lamotrigine belongs to Central Nervous System.
Why it happens
Estrogens induce glucuronidation (UGT) of lamotrigine, increasing its clearance.
What to do
Monitor seizure or mood control and lamotrigine response when estrogen therapy is started or stopped. Adjust the lamotrigine dose guided by clinical response or serum levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Lamotrigine
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Lamotrigine?
MediHelp rates the interaction as moderate. Bazedoxifene-conjugated estrogens and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estrogens can lower lamotrigine concentrations, as seen with estrogen-containing contraceptives. Reduced levels may lead to loss of seizure or mood control, and the effect may reverse when the estrogen is stopped.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Lamotrigine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure or mood control and lamotrigine response when estrogen therapy is started or stopped. Adjust the lamotrigine dose guided by clinical response or serum levels.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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