Drug interactions
Bazedoxifene-conjugated estrogens + Nafcillin
Severity: Moderate
Bazedoxifene-conjugated estrogens and Nafcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and may lower exposure to the estrogen and bazedoxifene components. Reduced bazedoxifene exposure may weaken endometrial protection, while lower estrogen levels may reduce symptom control.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 (and possibly UGT) increases the metabolism of the estrogen and bazedoxifene components.
What to do
Monitor for return of vasomotor symptoms and for abnormal uterine bleeding; consider an alternative antibiotic if nafcillin is needed for a prolonged course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Nafcillin?
MediHelp rates the interaction as moderate. Bazedoxifene-conjugated estrogens and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is a CYP3A4 inducer and may lower exposure to the estrogen and bazedoxifene components. Reduced bazedoxifene exposure may weaken endometrial protection, while lower estrogen levels may reduce symptom control.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Nafcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for return of vasomotor symptoms and for abnormal uterine bleeding; consider an alternative antibiotic if nafcillin is needed for a prolonged course.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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