Drug interactions
Bazedoxifene-conjugated estrogens + Nefazodone
Severity: Moderate
Bazedoxifene-conjugated estrogens and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and may increase exposure to the estrogen component and bazedoxifene. This could heighten estrogen-related adverse effects and endometrial stimulation.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by nefazodone reduces metabolism of the estrogen and bazedoxifene components.
What to do
Monitor for estrogenic adverse effects and unexpected vaginal bleeding. Consider an alternative antidepressant, as nefazodone is rarely first-line.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Nefazodone?
MediHelp rates the interaction as moderate. Bazedoxifene-conjugated estrogens and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a strong CYP3A4 inhibitor and may increase exposure to the estrogen component and bazedoxifene. This could heighten estrogen-related adverse effects and endometrial stimulation.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects and unexpected vaginal bleeding. Consider an alternative antidepressant, as nefazodone is rarely first-line.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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