Drug interactions
Bazedoxifene-conjugated estrogens + Phenindione
Severity: Major
Bazedoxifene-conjugated estrogens and Phenindione: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenindione is an oral vitamin K antagonist used for thrombosis. Estrogen therapy increases venous thromboembolism risk and may alter clotting factor levels, which can reduce anticoagulant control in patients being treated for thrombotic disease.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Estrogens raise procoagulant factor levels, opposing vitamin K antagonist effect.
What to do
Avoid this hormone product in patients requiring therapeutic anticoagulation for thrombosis. If the combination is used, monitor INR closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bazedoxifene-conjugated estrogens and Phenindione, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Phenindione?
MediHelp rates the interaction as major. Bazedoxifene-conjugated estrogens and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenindione is an oral vitamin K antagonist used for thrombosis. Estrogen therapy increases venous thromboembolism risk and may alter clotting factor levels, which can reduce anticoagulant control in patients being treated for thrombotic disease.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Phenindione?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid this hormone product in patients requiring therapeutic anticoagulation for thrombosis. If the combination is used, monitor INR closely.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
