Drug interactions
Bazedoxifene-conjugated estrogens + Phenobarbital
Severity: Moderate
Bazedoxifene-conjugated estrogens and Phenobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is a potent enzyme inducer and can reduce exposure to both estrogens and bazedoxifene. Lower bazedoxifene exposure may compromise endometrial protection and raise the risk of endometrial hyperplasia, and estrogen efficacy may fall.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 and UDP-glucuronosyltransferases increases metabolic clearance of the estrogen and bazedoxifene components.
What to do
Monitor for breakthrough bleeding and loss of symptom control, and evaluate the endometrium if abnormal bleeding occurs. Consider a non-inducing anticonvulsant if clinically feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Phenobarbital?
MediHelp rates the interaction as moderate. Bazedoxifene-conjugated estrogens and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital is a potent enzyme inducer and can reduce exposure to both estrogens and bazedoxifene. Lower bazedoxifene exposure may compromise endometrial protection and raise the risk of endometrial hyperplasia, and estrogen efficacy may fall.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough bleeding and loss of symptom control, and evaluate the endometrium if abnormal bleeding occurs. Consider a non-inducing anticonvulsant if clinically feasible.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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