Drug interactions
Bazedoxifene-conjugated estrogens + Protriptyline
Severity: Minor
Bazedoxifene-conjugated estrogens and Protriptyline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens may increase tricyclic antidepressant concentrations and adverse effects such as sedation, hypotension and anticholinergic effects, while the antidepressant effect may be reduced in some patients. Evidence is limited and mostly from older reports.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Protriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Proposed reduced hepatic metabolism of the tricyclic by estrogens; the mechanism is not firmly established.
What to do
Monitor for tricyclic adverse effects and for changes in depressive symptoms when estrogen is started or stopped, and adjust the protriptyline dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Protriptyline?
MediHelp rates the interaction as minor. Bazedoxifene-conjugated estrogens and Protriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens may increase tricyclic antidepressant concentrations and adverse effects such as sedation, hypotension and anticholinergic effects, while the antidepressant effect may be reduced in some patients. Evidence is limited and mostly from older reports.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Protriptyline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and for changes in depressive symptoms when estrogen is started or stopped, and adjust the protriptyline dose as needed.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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