Drug interactions
Bazedoxifene-conjugated estrogens + St john's wort
Severity: Moderate
Bazedoxifene-conjugated estrogens and St john's wort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
St John's wort induces drug-metabolising enzymes and may lower exposure to bazedoxifene and estrogens. This may reduce endometrial protection and symptom control, with breakthrough bleeding possible.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and St john's wort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 and UGT enzymes by hyperforin increases clearance of both components.
What to do
Advise the patient to avoid St John's wort while on this product. Evaluate any unexpected bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with St john's wort?
MediHelp rates the interaction as moderate. Bazedoxifene-conjugated estrogens and St john's wort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. St John's wort induces drug-metabolising enzymes and may lower exposure to bazedoxifene and estrogens. This may reduce endometrial protection and symptom control, with breakthrough bleeding possible.
How serious is the interaction between Bazedoxifene-conjugated estrogens and St john's wort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient to avoid St John's wort while on this product. Evaluate any unexpected bleeding.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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