Drug interactions
Bazedoxifene / conjugated estrogens + Verapamil
Severity: Minor
Bazedoxifene / conjugated estrogens and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may increase exposure to conjugated estrogens and bazedoxifene through CYP3A4 and P-gp inhibition. This could increase estrogenic and adverse effects, though clinical data are limited.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Verapamil inhibits CYP3A4 and P-gp, possibly raising levels of the estrogen and bazedoxifene components.
What to do
No routine dose change; monitor for estrogen-related adverse effects such as breast tenderness or bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Verapamil?
MediHelp rates the interaction as minor. Bazedoxifene / conjugated estrogens and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil may increase exposure to conjugated estrogens and bazedoxifene through CYP3A4 and P-gp inhibition. This could increase estrogenic and adverse effects, though clinical data are limited.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor for estrogen-related adverse effects such as breast tenderness or bleeding.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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