Drug interactions
Bcg vaccine live + Linezolid
Severity: Moderate
Bcg vaccine live and Linezolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibacterial activity of linezolid against mycobacteria and other bacteria may reduce replication of the live attenuated BCG organisms. This could reduce immune response and vaccine effectiveness.
What this interaction means in plain words
Bcg vaccine live and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibiotic action against the live bacterial vaccine strain reduces its viability and immunogenicity.
What to do
Delay BCG vaccination until antibiotic therapy is completed, or revaccinate if given during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Bcg vaccine live with Linezolid?
MediHelp rates the interaction as moderate. Bcg vaccine live and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antibacterial activity of linezolid against mycobacteria and other bacteria may reduce replication of the live attenuated BCG organisms. This could reduce immune response and vaccine effectiveness.
How serious is the interaction between Bcg vaccine live and Linezolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay BCG vaccination until antibiotic therapy is completed, or revaccinate if given during treatment.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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