Drug interactions
Bcg vaccine live + Oxaliplatin
Severity: Contraindicated
Bcg vaccine live and Oxaliplatin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
In patients immunosuppressed by oxaliplatin, live BCG may cause disseminated BCG infection and the vaccine may be less effective.
What this interaction means in plain words
Bcg vaccine live and Oxaliplatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Cytotoxic immunosuppression impairs control of live vaccine bacteria and reduces the immune response.
What to do
Do not give BCG during oxaliplatin therapy; defer until immune recovery, generally at least 3 months after treatment ends.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
- Measles vaccine + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Bcg vaccine live with Oxaliplatin?
MediHelp rates the interaction as contraindicated. Bcg vaccine live and Oxaliplatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. In patients immunosuppressed by oxaliplatin, live BCG may cause disseminated BCG infection and the vaccine may be less effective.
How serious is the interaction between Bcg vaccine live and Oxaliplatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give BCG during oxaliplatin therapy; defer until immune recovery, generally at least 3 months after treatment ends.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Oxaliplatin page.
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