Drug interactions
Measles mumps and rubella vaccine + Oxaliplatin
Severity: Contraindicated
Measles mumps and rubella vaccine and Oxaliplatin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin-based chemotherapy causes myelosuppression and immune suppression, so the response to the live vaccine may be reduced. Replication of the vaccine viruses may be uncontrolled, which can cause serious vaccine-strain disease.
What this interaction means in plain words
Measles mumps and rubella vaccine and Oxaliplatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Measles mumps and rubella vaccine belongs to Miscellaneous; Oxaliplatin belongs to Oncology.
Why it happens
Cytotoxic chemotherapy suppresses immune function, which blunts vaccine response and permits replication of live attenuated virus.
What to do
Do not give MMR during chemotherapy; give it at least 2 to 4 weeks before starting if feasible. After completion, delay vaccination for about 3 months and until immune recovery.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
- Measles vaccine + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Measles mumps and rubella vaccine with Oxaliplatin?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine and Oxaliplatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxaliplatin-based chemotherapy causes myelosuppression and immune suppression, so the response to the live vaccine may be reduced. Replication of the vaccine viruses may be uncontrolled, which can cause serious vaccine-strain disease.
How serious is the interaction between Measles mumps and rubella vaccine and Oxaliplatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give MMR during chemotherapy; give it at least 2 to 4 weeks before starting if feasible. After completion, delay vaccination for about 3 months and until immune recovery.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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