Drug interactions
Measles mumps rubella and varicella vaccine live + Oxaliplatin
Severity: Contraindicated
Measles mumps rubella and varicella vaccine live and Oxaliplatin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined live MMRV vaccine may cause disseminated vaccine-strain infection in patients immunosuppressed by oxaliplatin, and immunogenicity is reduced.
What this interaction means in plain words
Measles mumps rubella and varicella vaccine live and Oxaliplatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Cytotoxic immunosuppression impairs control of live vaccine virus replication and reduces the immune response.
What to do
Avoid during oxaliplatin therapy and until immune recovery, generally at least 3 months after stopping. Revaccinate once immunity has recovered.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles vaccine + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Measles mumps rubella and varicella vaccine live with Oxaliplatin?
MediHelp rates the interaction as contraindicated. Measles mumps rubella and varicella vaccine live and Oxaliplatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combined live MMRV vaccine may cause disseminated vaccine-strain infection in patients immunosuppressed by oxaliplatin, and immunogenicity is reduced.
How serious is the interaction between Measles mumps rubella and varicella vaccine live and Oxaliplatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during oxaliplatin therapy and until immune recovery, generally at least 3 months after stopping. Revaccinate once immunity has recovered.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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