Drug interactions
Measles mumps and rubella vaccine live + Sirolimus
Severity: Contraindicated
Measles mumps and rubella vaccine live and Sirolimus: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The live MMR vaccine may cause disseminated vaccine-strain infection in patients immunosuppressed with sirolimus, and immunogenicity may be poor.
What this interaction means in plain words
Measles mumps and rubella vaccine live and Sirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Sirolimus immunosuppression permits replication of live attenuated viruses and blunts vaccine response.
What to do
Do not administer during sirolimus therapy. Immunize before transplant or immunosuppression, and check immunity serologically.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine + Sirolimus Contraindicated
Frequently asked questions
Can I take Measles mumps and rubella vaccine live with Sirolimus?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine live and Sirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The live MMR vaccine may cause disseminated vaccine-strain infection in patients immunosuppressed with sirolimus, and immunogenicity may be poor.
How serious is the interaction between Measles mumps and rubella vaccine live and Sirolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not administer during sirolimus therapy. Immunize before transplant or immunosuppression, and check immunity serologically.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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