Drug interactions
Belatacept + Ustekinumab
Severity: Moderate
Belatacept and Ustekinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress immune function, so combining them may raise the risk of serious infections and possibly malignancy. Belatacept already carries warnings for infections and post-transplant lymphoproliferative disorder.
What this interaction means in plain words
Belatacept and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belatacept belongs to Miscellaneous; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression via IL-12/23 blockade and T-cell costimulation blockade.
What to do
Monitor for infection and reassess the ongoing need for both agents. Avoid live vaccines and screen for latent infections such as tuberculosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Belatacept
Frequently asked questions
Can I take Belatacept with Ustekinumab?
MediHelp rates the interaction as moderate. Belatacept and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress immune function, so combining them may raise the risk of serious infections and possibly malignancy. Belatacept already carries warnings for infections and post-transplant lymphoproliferative disorder.
How serious is the interaction between Belatacept and Ustekinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and reassess the ongoing need for both agents. Avoid live vaccines and screen for latent infections such as tuberculosis.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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