Drug interactions
Belimumab + Ifosfamide
Severity: Moderate
Belimumab and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belimumab reduces B-cell survival and ifosfamide causes myelosuppression and immune suppression, so combined use may raise infection risk. Clinical data on this specific pairing are limited and the concern is mainly predicted from their effects.
What this interaction means in plain words
Belimumab and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belimumab belongs to Miscellaneous; Ifosfamide belongs to Oncology.
Why it happens
Additive immunosuppression from B-lymphocyte stimulator inhibition and cytotoxic chemotherapy.
What to do
Monitor for infection and follow neutrophil counts during chemotherapy cycles. Hold belimumab if a serious infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Belimumab
- Belimumab + Measles mumps and rubella vaccine Major
- Abatacept + Belimumab Moderate
- Adalimumab + Belimumab Moderate
- Anakinra + Belimumab Moderate
- Anti-thymocyte + Belimumab Moderate
- Belimumab + Denosumab Moderate
Frequently asked questions
Can I take Belimumab with Ifosfamide?
MediHelp rates the interaction as moderate. Belimumab and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belimumab reduces B-cell survival and ifosfamide causes myelosuppression and immune suppression, so combined use may raise infection risk. Clinical data on this specific pairing are limited and the concern is mainly predicted from their effects.
How serious is the interaction between Belimumab and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and follow neutrophil counts during chemotherapy cycles. Hold belimumab if a serious infection develops.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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