Drug interactions
Belladonna alkaloids + Cyclizine
Severity: Moderate
Belladonna alkaloids and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna alkaloids such as atropine and hyoscyamine add to the antimuscarinic effects of cyclizine. This may produce dry mouth, constipation, urinary retention, tachycardia, confusion and heat intolerance.
What this interaction means in plain words
Belladonna alkaloids and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic toxicity, especially in elderly patients, and reduce doses or choose a non-anticholinergic antiemetic if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Belladonna alkaloids with Cyclizine?
MediHelp rates the interaction as moderate. Belladonna alkaloids and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna alkaloids such as atropine and hyoscyamine add to the antimuscarinic effects of cyclizine. This may produce dry mouth, constipation, urinary retention, tachycardia, confusion and heat intolerance.
How serious is the interaction between Belladonna alkaloids and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in elderly patients, and reduce doses or choose a non-anticholinergic antiemetic if symptoms develop.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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