Drug interactions
Belladonna alkaloids + Flavoxate
Severity: Moderate
Belladonna alkaloids and Flavoxate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna alkaloids such as atropine, hyoscyamine and scopolamine are antimuscarinic, and combining them with flavoxate increases anticholinergic effects. Dry mouth, constipation, urinary retention, tachycardia and confusion may occur.
What this interaction means in plain words
Belladonna alkaloids and Flavoxate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic toxicity, especially in older patients, and avoid duplicate therapy where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flavoxate
- Clozapine + Flavoxate Major
- Abobotulinumtoxina + Flavoxate Moderate
- Aclidinium + Flavoxate Moderate
- Amantadine + Flavoxate Moderate
- Amitriptyline + Flavoxate Moderate
- Amoxapine + Flavoxate Moderate
Frequently asked questions
Can I take Belladonna alkaloids with Flavoxate?
MediHelp rates the interaction as moderate. Belladonna alkaloids and Flavoxate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna alkaloids such as atropine, hyoscyamine and scopolamine are antimuscarinic, and combining them with flavoxate increases anticholinergic effects. Dry mouth, constipation, urinary retention, tachycardia and confusion may occur.
How serious is the interaction between Belladonna alkaloids and Flavoxate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in older patients, and avoid duplicate therapy where possible.
What other medicines interact with Flavoxate?
MediHelp also lists interactions of Flavoxate with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Flavoxate page.
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