Drug interactions
Belladonna alkaloids + Loxapine
Severity: Moderate
Belladonna alkaloids and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna alkaloids are antimuscarinic, and loxapine has anticholinergic effects. Together they can cause dry mouth, urinary retention, constipation, blurred vision, tachycardia and confusion, particularly in elderly patients.
What this interaction means in plain words
Belladonna alkaloids and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic toxicity and avoid in patients with narrow-angle glaucoma, urinary retention or ileus. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Belladonna alkaloids with Loxapine?
MediHelp rates the interaction as moderate. Belladonna alkaloids and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna alkaloids are antimuscarinic, and loxapine has anticholinergic effects. Together they can cause dry mouth, urinary retention, constipation, blurred vision, tachycardia and confusion, particularly in elderly patients.
How serious is the interaction between Belladonna alkaloids and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and avoid in patients with narrow-angle glaucoma, urinary retention or ileus. Use the lowest effective doses.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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