Drug interactions
Apomorphine + Loxapine
Severity: Major
Apomorphine and Loxapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine is a dopamine agonist and loxapine blocks dopamine D2 receptors, so they work against each other. The antipsychotic may reduce the antiparkinsonian effect of apomorphine.
What this interaction means in plain words
Apomorphine and Loxapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apomorphine belongs to Central Nervous System; Loxapine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Avoid the combination in Parkinson disease and select an antipsychotic with little D2 antagonism, such as quetiapine or clozapine, if one is required.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Loxapine
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Loxapine?
MediHelp rates the interaction as major. Apomorphine and Loxapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apomorphine is a dopamine agonist and loxapine blocks dopamine D2 receptors, so they work against each other. The antipsychotic may reduce the antiparkinsonian effect of apomorphine.
How serious is the interaction between Apomorphine and Loxapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in Parkinson disease and select an antipsychotic with little D2 antagonism, such as quetiapine or clozapine, if one is required.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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