Drug interactions
Belladonna alkaloids + Maprotiline
Severity: Moderate
Belladonna alkaloids and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both have antimuscarinic activity, so combined use can cause marked dry mouth, constipation, urinary retention, tachycardia, blurred vision and confusion. Older adults and those with glaucoma or obstruction are most vulnerable.
What this interaction means in plain words
Belladonna alkaloids and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic toxicity and reduce doses or use alternatives if symptoms occur. Avoid in narrow-angle glaucoma and urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Belladonna alkaloids with Maprotiline?
MediHelp rates the interaction as moderate. Belladonna alkaloids and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both have antimuscarinic activity, so combined use can cause marked dry mouth, constipation, urinary retention, tachycardia, blurred vision and confusion. Older adults and those with glaucoma or obstruction are most vulnerable.
How serious is the interaction between Belladonna alkaloids and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and reduce doses or use alternatives if symptoms occur. Avoid in narrow-angle glaucoma and urinary retention.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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