Drug interactions
Belladonna alkaloids + Orphenadrin
Severity: Moderate
Belladonna alkaloids and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are antimuscarinic, so combined use can cause additive dry mouth, tachycardia, constipation, urinary retention, blurred vision and confusion. Elderly patients are especially susceptible.
What this interaction means in plain words
Belladonna alkaloids and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic toxicity and use the lowest effective doses. Avoid in patients with narrow-angle glaucoma, urinary obstruction or ileus.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Frequently asked questions
Can I take Belladonna alkaloids with Orphenadrin?
MediHelp rates the interaction as moderate. Belladonna alkaloids and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are antimuscarinic, so combined use can cause additive dry mouth, tachycardia, constipation, urinary retention, blurred vision and confusion. Elderly patients are especially susceptible.
How serious is the interaction between Belladonna alkaloids and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and use the lowest effective doses. Avoid in patients with narrow-angle glaucoma, urinary obstruction or ileus.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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