Drug interactions
Belladonna alkaloids + Thioridazine
Severity: Moderate
Belladonna alkaloids and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna alkaloids and thioridazine both block muscarinic receptors, so the combination increases dry mouth, constipation, urinary retention, blurred vision and confusion. Reduced gut motility may also alter oral absorption.
What this interaction means in plain words
Belladonna alkaloids and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic toxicity and consider reducing the belladonna dose, especially in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Belladonna alkaloids with Thioridazine?
MediHelp rates the interaction as moderate. Belladonna alkaloids and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna alkaloids and thioridazine both block muscarinic receptors, so the combination increases dry mouth, constipation, urinary retention, blurred vision and confusion. Reduced gut motility may also alter oral absorption.
How serious is the interaction between Belladonna alkaloids and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and consider reducing the belladonna dose, especially in elderly patients.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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