Drug interactions
Belladonna alkaloids + Tiotropium
Severity: Moderate
Belladonna alkaloids and Tiotropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna alkaloids such as atropine and hyoscyamine are antimuscarinics that add to the effects of tiotropium. This increases the risk of dry mouth, constipation, urinary retention, tachycardia and raised intraocular pressure.
What this interaction means in plain words
Belladonna alkaloids and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid unnecessary combined use; monitor for urinary retention, tachycardia and eye symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium
Frequently asked questions
Can I take Belladonna alkaloids with Tiotropium?
MediHelp rates the interaction as moderate. Belladonna alkaloids and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna alkaloids such as atropine and hyoscyamine are antimuscarinics that add to the effects of tiotropium. This increases the risk of dry mouth, constipation, urinary retention, tachycardia and raised intraocular pressure.
How serious is the interaction between Belladonna alkaloids and Tiotropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary combined use; monitor for urinary retention, tachycardia and eye symptoms.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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