Drug interactions
Belladonna alkaloids + Umeclidinium-vilanterol
Severity: Moderate
Belladonna alkaloids and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Umeclidinium is an inhaled antimuscarinic, and belladonna alkaloids are systemic antimuscarinics. Using both can add up anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision, tachycardia and raised intraocular pressure.
What this interaction means in plain words
Belladonna alkaloids and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive blockade of muscarinic receptors.
What to do
Avoid routine combined use where possible, and monitor for urinary retention, constipation and worsening of narrow-angle glaucoma. Reduce or stop the systemic anticholinergic if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Frequently asked questions
Can I take Belladonna alkaloids with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Belladonna alkaloids and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Umeclidinium is an inhaled antimuscarinic, and belladonna alkaloids are systemic antimuscarinics. Using both can add up anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision, tachycardia and raised intraocular pressure.
How serious is the interaction between Belladonna alkaloids and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combined use where possible, and monitor for urinary retention, constipation and worsening of narrow-angle glaucoma. Reduce or stop the systemic anticholinergic if symptoms appear.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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