Drug interactions
Belladonna alkaloids + Ziprasidone
Severity: Moderate
Belladonna alkaloids and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna alkaloids have anticholinergic effects that may add to the mild anticholinergic and sedative effects of ziprasidone. This can cause dry mouth, constipation, urinary retention, confusion and tachycardia, particularly in older adults.
What this interaction means in plain words
Belladonna alkaloids and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects and CNS depression.
What to do
Monitor for anticholinergic toxicity and sedation, especially in elderly patients. Reduce the dose or choose an alternative antispasmodic if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Belladonna alkaloids with Ziprasidone?
MediHelp rates the interaction as moderate. Belladonna alkaloids and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna alkaloids have anticholinergic effects that may add to the mild anticholinergic and sedative effects of ziprasidone. This can cause dry mouth, constipation, urinary retention, confusion and tachycardia, particularly in older adults.
How serious is the interaction between Belladonna alkaloids and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and sedation, especially in elderly patients. Reduce the dose or choose an alternative antispasmodic if symptoms develop.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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