Drug interactions
Brompheniramine + Dipipanone
Severity: Major
Brompheniramine and Dipipanone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipipanone is a strong opioid, and a sedating antihistamine increases the risk of excessive sedation and respiratory depression.
What this interaction means in plain words
Brompheniramine and Dipipanone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via opioid agonism and H1 antagonism.
What to do
Avoid if possible; otherwise use the lowest doses and monitor sedation and respiratory rate. Prefer a non-sedating antihistamine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Dipipanone?
MediHelp rates the interaction as major. Brompheniramine and Dipipanone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dipipanone is a strong opioid, and a sedating antihistamine increases the risk of excessive sedation and respiratory depression.
How serious is the interaction between Brompheniramine and Dipipanone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise use the lowest doses and monitor sedation and respiratory rate. Prefer a non-sedating antihistamine.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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