Drug interactions
Belladonna and opium + Cimetidine
Severity: Moderate
Belladonna and opium and Cimetidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may reduce hepatic metabolism of the opium (morphine) component, increasing opioid effects. Excess sedation and respiratory depression are possible.
What this interaction means in plain words
Belladonna and opium and Cimetidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cimetidine inhibits hepatic CYP enzymes, slowing opioid metabolism.
What to do
Monitor for sedation and respiratory depression and reduce the opioid dose if needed. Consider famotidine as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Belladonna and opium with Cimetidine?
MediHelp rates the interaction as moderate. Belladonna and opium and Cimetidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine may reduce hepatic metabolism of the opium (morphine) component, increasing opioid effects. Excess sedation and respiratory depression are possible.
How serious is the interaction between Belladonna and opium and Cimetidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and reduce the opioid dose if needed. Consider famotidine as an alternative.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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