Drug interactions
Belladonna and opium + Clorazepate
Severity: Major
Belladonna and opium and Clorazepate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The opium component adds opioid effects to the benzodiazepine, risking profound sedation, respiratory depression and death. Belladonna alkaloids add anticholinergic confusion.
What this interaction means in plain words
Belladonna and opium and Clorazepate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid receptor agonism and GABA-A potentiation.
What to do
Avoid combining where possible; if necessary, use the lowest effective doses for the shortest duration and monitor respiratory status and sedation. Counsel patients and caregivers on warning signs of overdose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Belladonna and opium and Clorazepate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Benzhydrocodone / acetaminophen + Clorazepate Major
Frequently asked questions
Can I take Belladonna and opium with Clorazepate?
MediHelp rates the interaction as major. Belladonna and opium and Clorazepate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The opium component adds opioid effects to the benzodiazepine, risking profound sedation, respiratory depression and death. Belladonna alkaloids add anticholinergic confusion.
How serious is the interaction between Belladonna and opium and Clorazepate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if necessary, use the lowest effective doses for the shortest duration and monitor respiratory status and sedation. Counsel patients and caregivers on warning signs of overdose.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
