Drug interactions
Clorazepate + Sodium oxybate
Severity: Contraindicated
Clorazepate and Sodium oxybate: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium oxybate is a potent CNS depressant, and with a benzodiazepine it can cause profound sedation, respiratory depression, coma and death. Labeling restricts concomitant use with sedatives.
What this interaction means in plain words
Clorazepate and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clorazepate belongs to Central Nervous System; Sodium oxybate belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression via GABA-B and GABA-A mediated effects.
What to do
Avoid the combination and choose an alternative to the benzodiazepine where possible. If unavoidable, monitor closely for respiratory depression.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Clorazepate
Other interactions of Sodium oxybate
- Alprazolam + Sodium oxybate Contraindicated
- Amobarbital + Sodium oxybate Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Eszopiclone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Clorazepate with Sodium oxybate?
MediHelp rates the interaction as contraindicated. Clorazepate and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sodium oxybate is a potent CNS depressant, and with a benzodiazepine it can cause profound sedation, respiratory depression, coma and death. Labeling restricts concomitant use with sedatives.
How serious is the interaction between Clorazepate and Sodium oxybate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative to the benzodiazepine where possible. If unavoidable, monitor closely for respiratory depression.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Clorazepate page.
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