Drug interactions
Calcium / magnesium / potassium / sodium oxybates + Clorazepate
Severity: Contraindicated
Calcium / magnesium / potassium / sodium oxybates and Clorazepate: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybates are potent CNS depressants, and with a benzodiazepine they can cause profound sedation, respiratory depression, coma and death. Use with sedatives is generally contraindicated or restricted by labeling.
What this interaction means in plain words
Calcium / magnesium / potassium / sodium oxybates and Clorazepate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive CNS and respiratory depression via GABA-B and GABA-A mediated effects.
What to do
Avoid the combination; if a benzodiazepine is essential, consider an alternative to the oxybate or stop one agent. If unavoidable, monitor closely for respiratory depression.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Clorazepate
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
- Benzhydrocodone / acetaminophen + Clorazepate Major
Frequently asked questions
Can I take Calcium / magnesium / potassium / sodium oxybates with Clorazepate?
MediHelp rates the interaction as contraindicated. Calcium / magnesium / potassium / sodium oxybates and Clorazepate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxybates are potent CNS depressants, and with a benzodiazepine they can cause profound sedation, respiratory depression, coma and death. Use with sedatives is generally contraindicated or restricted by labeling.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Clorazepate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if a benzodiazepine is essential, consider an alternative to the oxybate or stop one agent. If unavoidable, monitor closely for respiratory depression.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Sodium oxybate, Alfentanil, Alprazolam. The full list is on the Clorazepate page.
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