Drug interactions
Belladonna and opium + Cyclizine
Severity: Moderate
Belladonna and opium and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This combination adds anticholinergic effects from belladonna to sedation and respiratory depression from opium, on top of cyclizine's own sedative and antimuscarinic effects. It can cause marked drowsiness, constipation, urinary retention and slowed breathing.
What this interaction means in plain words
Belladonna and opium and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects and CNS/respiratory depression from opioid and antihistamine.
What to do
Monitor sedation, respiratory rate and bowel and bladder function, and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Belladonna and opium with Cyclizine?
MediHelp rates the interaction as moderate. Belladonna and opium and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This combination adds anticholinergic effects from belladonna to sedation and respiratory depression from opium, on top of cyclizine's own sedative and antimuscarinic effects. It can cause marked drowsiness, constipation, urinary retention and slowed breathing.
How serious is the interaction between Belladonna and opium and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory rate and bowel and bladder function, and use the lowest effective doses.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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