Drug interactions
Belladonna and opium + Desipramine
Severity: Moderate
Belladonna and opium and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination adds anticholinergic effects from belladonna and desipramine, and sedation and respiratory depression from opium alongside the tricyclic. This may cause urinary retention, severe constipation, ileus, confusion and oversedation.
What this interaction means in plain words
Belladonna and opium and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects and additive CNS and respiratory depression.
What to do
Monitor sedation, respiratory rate, bowel function and urinary output. Use the lowest effective doses and avoid in patients prone to ileus or urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Belladonna and opium with Desipramine?
MediHelp rates the interaction as moderate. Belladonna and opium and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination adds anticholinergic effects from belladonna and desipramine, and sedation and respiratory depression from opium alongside the tricyclic. This may cause urinary retention, severe constipation, ileus, confusion and oversedation.
How serious is the interaction between Belladonna and opium and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory rate, bowel function and urinary output. Use the lowest effective doses and avoid in patients prone to ileus or urinary retention.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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