Drug interactions
Belladonna and opium + Eltrombopag
Severity: Minor
Belladonna and opium and Eltrombopag: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Morphine, the main opium alkaloid, is cleared by UGT2B7 glucuronidation. Eltrombopag inhibits UGT enzymes in vitro, so opioid exposure might increase, though the clinical relevance is unproven.
What this interaction means in plain words
Belladonna and opium and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
In vitro UGT inhibition by eltrombopag may reduce morphine glucuronidation.
What to do
Monitor for excess sedation and respiratory depression when starting eltrombopag. Reduce the opioid dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Belladonna and opium with Eltrombopag?
MediHelp rates the interaction as minor. Belladonna and opium and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Morphine, the main opium alkaloid, is cleared by UGT2B7 glucuronidation. Eltrombopag inhibits UGT enzymes in vitro, so opioid exposure might increase, though the clinical relevance is unproven.
How serious is the interaction between Belladonna and opium and Eltrombopag?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and respiratory depression when starting eltrombopag. Reduce the opioid dose if these occur.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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