Drug interactions
Belladonna and opium + Flavoxate
Severity: Moderate
Belladonna and opium and Flavoxate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The belladonna component adds antimuscarinic effects to flavoxate, and the opium component also slows gut and urinary tract motility. Together they raise the risk of urinary retention, constipation and ileus, with additional sedation from the opioid.
What this interaction means in plain words
Belladonna and opium and Flavoxate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic antagonism, plus opioid-mediated reduction in smooth muscle motility and CNS depression.
What to do
Monitor for urinary retention, constipation, abdominal distension and sedation. Adjust or stop one agent if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Belladonna and opium and Flavoxate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Flavoxate
- Clozapine + Flavoxate Major
- Abobotulinumtoxina + Flavoxate Moderate
- Aclidinium + Flavoxate Moderate
- Amantadine + Flavoxate Moderate
- Amitriptyline + Flavoxate Moderate
- Amoxapine + Flavoxate Moderate
Frequently asked questions
Can I take Belladonna and opium with Flavoxate?
MediHelp rates the interaction as moderate. Belladonna and opium and Flavoxate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The belladonna component adds antimuscarinic effects to flavoxate, and the opium component also slows gut and urinary tract motility. Together they raise the risk of urinary retention, constipation and ileus, with additional sedation from the opioid.
How serious is the interaction between Belladonna and opium and Flavoxate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation, abdominal distension and sedation. Adjust or stop one agent if these occur.
What other medicines interact with Flavoxate?
MediHelp also lists interactions of Flavoxate with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Flavoxate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
