Drug interactions
Belladonna and opium + Lidocaine-prilocaine
Severity: Minor
Belladonna and opium and Lidocaine-prilocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic lidocaine may add slightly to opioid-related CNS depression, but topical lidocaine-prilocaine produces low systemic levels. The effect is expected to be small.
What this interaction means in plain words
Belladonna and opium and Lidocaine-prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression from systemic lidocaine with the opioid.
What to do
No routine action is needed with limited topical use. Monitor for excessive sedation when large areas are treated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Frequently asked questions
Can I take Belladonna and opium with Lidocaine-prilocaine?
MediHelp rates the interaction as minor. Belladonna and opium and Lidocaine-prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic lidocaine may add slightly to opioid-related CNS depression, but topical lidocaine-prilocaine produces low systemic levels. The effect is expected to be small.
How serious is the interaction between Belladonna and opium and Lidocaine-prilocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed with limited topical use. Monitor for excessive sedation when large areas are treated.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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