Drug interactions
Belladonna and opium + Maprotiline
Severity: Major
Belladonna and opium and Maprotiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This combination adds antimuscarinic effects from belladonna to those of maprotiline, and opium adds opioid sedation and respiratory depression. It can cause oversedation, constipation, urinary retention and confusion.
What this interaction means in plain words
Belladonna and opium and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive anticholinergic effects and additive CNS and respiratory depression from the opioid.
What to do
Avoid if possible, or use the lowest doses with monitoring of sedation, respiratory rate and bowel and bladder function. Counsel patients to avoid alcohol and other depressants.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Belladonna and opium with Maprotiline?
MediHelp rates the interaction as major. Belladonna and opium and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. This combination adds antimuscarinic effects from belladonna to those of maprotiline, and opium adds opioid sedation and respiratory depression. It can cause oversedation, constipation, urinary retention and confusion.
How serious is the interaction between Belladonna and opium and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or use the lowest doses with monitoring of sedation, respiratory rate and bowel and bladder function. Counsel patients to avoid alcohol and other depressants.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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