Drug interactions
Belladonna and opium + Nabilone
Severity: Major
Belladonna and opium and Nabilone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The opium component adds central and respiratory depression to nabilone's sedative effects, and the belladonna alkaloids add anticholinergic effects such as confusion and tachycardia. Combined use can notably impair alertness and breathing.
What this interaction means in plain words
Belladonna and opium and Nabilone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid and cannabinoid, plus anticholinergic effects.
What to do
Avoid if possible; otherwise use the lowest doses and monitor sedation and respiratory rate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nabilone
- Alfentanil + Nabilone Major
- Amobarbital + Nabilone Major
- Buprenorphine buccal + Nabilone Major
- Buprenorphine + Nabilone Major
- Butabarbital + Nabilone Major
- Butorphanol + Nabilone Major
Frequently asked questions
Can I take Belladonna and opium with Nabilone?
MediHelp rates the interaction as major. Belladonna and opium and Nabilone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The opium component adds central and respiratory depression to nabilone's sedative effects, and the belladonna alkaloids add anticholinergic effects such as confusion and tachycardia. Combined use can notably impair alertness and breathing.
How serious is the interaction between Belladonna and opium and Nabilone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise use the lowest doses and monitor sedation and respiratory rate.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Buprenorphine buccal. The full list is on the Nabilone page.
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