Drug interactions
Amobarbital + Nabilone
Severity: Major
Amobarbital and Nabilone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital is a barbiturate with strong sedative effects, and nabilone also causes drowsiness and impaired coordination. The combination can cause profound sedation and respiratory depression.
What this interaction means in plain words
Amobarbital and Nabilone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive CNS and respiratory depression.
What to do
Avoid the combination if possible; otherwise use reduced doses and monitor sedation and respiratory rate closely. Advise patients against driving and alcohol use.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nabilone
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Nabilone?
MediHelp rates the interaction as major. Amobarbital and Nabilone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital is a barbiturate with strong sedative effects, and nabilone also causes drowsiness and impaired coordination. The combination can cause profound sedation and respiratory depression.
How serious is the interaction between Amobarbital and Nabilone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise use reduced doses and monitor sedation and respiratory rate closely. Advise patients against driving and alcohol use.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Belladonna and opium, Buprenorphine buccal. The full list is on the Nabilone page.
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