Drug interactions
Butabarbital + Nabilone
Severity: Major
Butabarbital and Nabilone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates and nabilone each cause CNS depression, so together they can produce marked drowsiness, impaired coordination and reduced respiratory drive.
What this interaction means in plain words
Butabarbital and Nabilone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive central nervous system depression.
What to do
Avoid combining where possible; if necessary, reduce doses and monitor sedation and breathing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nabilone
Frequently asked questions
Can I take Butabarbital with Nabilone?
MediHelp rates the interaction as major. Butabarbital and Nabilone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and nabilone each cause CNS depression, so together they can produce marked drowsiness, impaired coordination and reduced respiratory drive.
How serious is the interaction between Butabarbital and Nabilone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if necessary, reduce doses and monitor sedation and breathing.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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