Drug interactions
Belladonna and opium + Nalbuphine
Severity: Moderate
Belladonna and opium and Nalbuphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nalbuphine may blunt the effect of the opium component and precipitate withdrawal in opioid-dependent patients. Both also cause sedation and respiratory depression.
What this interaction means in plain words
Belladonna and opium and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competitive mu-receptor antagonism by a mixed agonist-antagonist plus additive CNS depression.
What to do
Avoid giving nalbuphine to patients on regular opioids unless the effect is intended. Monitor for withdrawal, reduced analgesia and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Frequently asked questions
Can I take Belladonna and opium with Nalbuphine?
MediHelp rates the interaction as moderate. Belladonna and opium and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nalbuphine may blunt the effect of the opium component and precipitate withdrawal in opioid-dependent patients. Both also cause sedation and respiratory depression.
How serious is the interaction between Belladonna and opium and Nalbuphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving nalbuphine to patients on regular opioids unless the effect is intended. Monitor for withdrawal, reduced analgesia and sedation.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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