Drug interactions
Belladonna and opium + Pancuronium
Severity: Minor
Belladonna and opium and Pancuronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna adds antimuscarinic effects to the vagolytic activity of pancuronium, and opium adds opioid effects. Tachycardia and antimuscarinic effects may be additive, and the product is usually given rectally.
What this interaction means in plain words
Belladonna and opium and Pancuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive cardiac muscarinic receptor blockade.
What to do
Monitor heart rate and ECG during anesthesia, particularly in patients with cardiac disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pancuronium
Frequently asked questions
Can I take Belladonna and opium with Pancuronium?
MediHelp rates the interaction as minor. Belladonna and opium and Pancuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Belladonna adds antimuscarinic effects to the vagolytic activity of pancuronium, and opium adds opioid effects. Tachycardia and antimuscarinic effects may be additive, and the product is usually given rectally.
How serious is the interaction between Belladonna and opium and Pancuronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG during anesthesia, particularly in patients with cardiac disease.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Pancuronium page.
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