Drug interactions
Belladonna and opium + Procarbazine
Severity: Moderate
Belladonna and opium and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine can enhance the CNS depressant effects of opioids, and opium contributes additive sedation and respiratory depression. Belladonna adds anticholinergic effects, and MAO inhibition may amplify some of these.
What this interaction means in plain words
Belladonna and opium and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with procarbazine's MAO inhibition possibly potentiating opioid effects.
What to do
Start with reduced opioid doses and monitor sedation and respiratory rate. Avoid concurrent alcohol and other CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Belladonna and opium with Procarbazine?
MediHelp rates the interaction as moderate. Belladonna and opium and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine can enhance the CNS depressant effects of opioids, and opium contributes additive sedation and respiratory depression. Belladonna adds anticholinergic effects, and MAO inhibition may amplify some of these.
How serious is the interaction between Belladonna and opium and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with reduced opioid doses and monitor sedation and respiratory rate. Avoid concurrent alcohol and other CNS depressants.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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