Drug interactions
Belladonna and opium + Quetiapine
Severity: Major
Belladonna and opium and Quetiapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opium adds opioid sedation and respiratory depression to the sedative effect of quetiapine, while belladonna adds anticholinergic effects. The combination can cause marked drowsiness, constipation, urinary retention, hypotension and respiratory depression.
What this interaction means in plain words
Belladonna and opium and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from the opioid, plus additive anticholinergic effects.
What to do
Use the lowest effective doses and monitor sedation, respiration, blood pressure and bowel and bladder function. Counsel against alcohol and other sedatives, and consider a non-opioid alternative if possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Belladonna and opium with Quetiapine?
MediHelp rates the interaction as major. Belladonna and opium and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opium adds opioid sedation and respiratory depression to the sedative effect of quetiapine, while belladonna adds anticholinergic effects. The combination can cause marked drowsiness, constipation, urinary retention, hypotension and respiratory depression.
How serious is the interaction between Belladonna and opium and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, respiration, blood pressure and bowel and bladder function. Counsel against alcohol and other sedatives, and consider a non-opioid alternative if possible.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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