Drug interactions
Belladonna and opium + Tiotropium
Severity: Moderate
Belladonna and opium and Tiotropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The belladonna component adds antimuscarinic effects to tiotropium, and the opium component can cause constipation and urinary retention. Together these may worsen urinary retention and constipation.
What this interaction means in plain words
Belladonna and opium and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects, with opioid-related reduced gut and bladder motility.
What to do
Monitor bowel function and urination; avoid use in patients with urinary obstruction or ileus risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium
Frequently asked questions
Can I take Belladonna and opium with Tiotropium?
MediHelp rates the interaction as moderate. Belladonna and opium and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The belladonna component adds antimuscarinic effects to tiotropium, and the opium component can cause constipation and urinary retention. Together these may worsen urinary retention and constipation.
How serious is the interaction between Belladonna and opium and Tiotropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and urination; avoid use in patients with urinary obstruction or ileus risk.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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